A Latent Pharmacokinetic Time Profile to Model Dose-Response Survival Data
نویسندگان
چکیده
منابع مشابه
A latent pharmacokinetic time profile to model dose-response survival data.
The accelerating rotarod test is a preclinical pharmacodynamic test to assess the effect of a treatment on an animal's motor coordination. Two models are proposed to analyze the dose-response time-to-event data that typically result from such experiments: (1) a linear regression model and (2) an E(max) model with latent drug concentration at the site of action. Both cope with the survival chara...
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ژورنال
عنوان ژورنال: Journal of Biopharmaceutical Statistics
سال: 2010
ISSN: 1054-3406,1520-5711
DOI: 10.1080/10543401003618249